WebT1 - Lipophilic statin versus rosuvastatin (Hydrophilic) treatment for heart failure. T2 - a meta-analysis and adjusted indirect comparison of randomised trials. AU - Bonsu, … WebSep 6, 2024 · Lipophilic statins include atorvastatin, simvastatin, lovastatin, fluvastatin, cerivastatin, and pitavastatin, while hydrophilic statins include rosuvastatin and pravastatin . The lipophilicity or hydrophilicity of statins is important for their pharmacokinetics and pharmacodynamics, and these characteristics are considered to be crucial for at least …
Chemical, pharmacokinetic and pharmacodynamic ... - Wiley …
WebAs a hydroxy-acid analog, fluvastatin has intermediate physiochemical properties, being about twice as hydrophilic as lovastatin and about 40 times more lipophilic than pravastatin. 62 In contrast to other statins, orally administered fluvastatin is nearly completely absorbed. WebAims: There are insufficient direct comparative studies addressing the impact of the type of statin on their respective efficacy in heart failure (HF). The aim of the current study was to compare the effects of lipophilic (atorvastatin) vs hydrophilic (rosuvastatin) on left ventricular function, inflammatory and fibrosis biomarkers in patients with chronic HF. ozark theatre rolla mo
Rosuvastatin and Colchicine combined myotoxicity: lessons to be …
WebJan 22, 2024 · Lipophilic statins include atorvastatin, simvastatin, lovastatin, fluvastatin, cerivastatin and pitavastatin, while hydrophilic statins include rosuvastatin and … WebOct 6, 2014 · The estimated average hydrophilic interaction between HMG CoA Reductase amino acid residues and rosuvastatin calculated by summing the individual coulombic interactions in water (shown in Table 2) is −34.9 kcal/mol for the hydrophilic interactions, which compares to the value of −37.6 kcal/mol (for the CDS first solvent shell only, which … WebRosuvastatin (RSV) is a member of this class that is mainly distributed to liver cells with low peripheral tissue distribution. ... (X 4), surfactant hydrophilic–lipophilic balance (HLB) (X 5) and surfactant concentration (X 6) were studied as independent variables. jelly belly factory facts free