WebJan 10, 2024 · Pten-null prostate cancers are poorly T cell infiltrated and resistant to anti-PD-1 immunotherapy. Most prostate cancers are immunogenically “cold” with low number of infiltrating T cells ... WebMay 23, 2024 · Lung cancer is the most common solid tumor in the worldwide. Targeted therapy and immunotherapy are important treatment options in advanced non-small cell lung cancer (NSCLC). The association of PTEN mutation and tumor immunotherapy is less established for patients with NSCLC. We present the case of an Asian woman diagnosed …
Modulating the tumor microenvironment via oncolytic virus and
WebMay 28, 2024 · e21161 Background: Patients with non-small cell lung cancer (NSCLC) harboring PTEN mutations have a worse prognosis of immunotherapy in research with small sample size and case reports. However, the role of PTEN and TP53 co-mutations in immunotherapy of NSCLC has not been fully studied. Methods: Patients with NSCLC from … WebFeb 4, 2016 · Because PTEN loss is most common in patients with melanoma with concurrent BRAF mutations, we silenced PTEN expression in established BRAF-mutant human melanoma cell lines and evaluated antitumor response to T cell–mediated immunotherapy using our previously described melanoma model (Supplementary Fig. … different basic skills in basketball
IJMS Free Full-Text Immunotherapy in Advanced Prostate …
WebJan 10, 2024 · Pten-null prostate cancers are poorly T cell infiltrated and resistant to anti-PD-1 immunotherapy. Most prostate cancers are immunogenically “cold” with low number of … WebThe effect of vaccination or adoptive immunotherapy on luciferase marked PTEN-CaP8 subcutaneous tumors was monitored by tumor volumetric measurements and noninvasive bioluminescence imaging. Results: Vaccination of litter mate mice with irradiated PTEN-CaP8 cells showed a significant prophylactic effect against the subsequent tumor … WebFeb 4, 2016 · In their study, Peng and colleagues present data that help address these important questions. The investigators present evidence that inactivation of PTEN in … different bases math