Phospho-acss2

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August undefined, 2024

WebDeacetylates ACSS2 leading to its activation, and HMGCS1. Involved in liver and muscle metabolism. ... All lanes : Anti-SIRT1 (phospho T530) antibody [EPNCIR153] (ab156585) at 1/1000 dilution Lane 1 : 293T cell lysates Lane 2 : 293T cell lysates treated with Calyculin A Lysates/proteins at 10 µg per lane. Secondary WebNov 12, 2024 · ACSS2 is the only known enzyme that can recycle acetate derived from deacetylation reactions in the cytoplasm and nucleus of cells, including both protein and metabolite deacetylation reactions. As such, ACSS2 can recycle acetate derived from histone deacetylase reactions as well as protein deacetylation reactions mediated by …

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WebDownload scientific diagram Cdk5 and p35 are important for proliferation of human TT cells. A, lysates of TT cells were immunoblotted by specific antibodies of Cdk5 and p35 with variant loading ... WebJun 11, 2024 · Abstract. Autophagy is an intracellular degenerative pathway which is responsible for neuronal survival. Under the condition of nutrient deprivation, autophagy can lead to dysfunction in memory consolidation. … flutter methodcall arguments

O-GlcNAc transferase regulates glioblastoma acetate …

WebACSS2 / ACAS2 is a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate ... WebTreatment with biguanides, but not isotretinoin, significantly upregulated ACSS2 gene expression in primary sebocytes and showed synergism with lipogenic activators to induce DNL genes. ... Phospho-mTOR signals were determined by absorbance at 450nm using a SpectraMax iD3 plate reader (Molecular Devices, San Jose, CA). Statistical Analysis. green headed small bird

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains …

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WebAnti-ACSS2 Antibody (A-9) is a mouse monoclonal IgG 1 κ ACSS2 antibody, cited in 5 publications, provided at 200 µg/ml raised against amino acids 1-160 mapping at the N-terminus of ACSS2 of human origin Anti-ACSS2 Antibody (A-9) is recommended for detection of ACSS2 of mouse, rat and human origin by WB, IP, IF and ELISA WebJan 12, 2015 · ACSS2 exhibits copy-number gain in human breast tumors, and ACSS2 expression correlates with disease progression. These results signify a critical role for acetate consumption in the production of lipid biomass within the harsh tumor microenvironment. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights … green headed hummingbirdWebIn the nucleus, ACSS2 binds to transcription factor EB and translocates to lysosomal and autophagy gene promoter regions, where ACSS2 incorporates acetate generated from … green headed flies bites

"WebACSS2(Phospho-Ser659) Antibody Orders: [email protected] Support: [email protected] Catalog No: #58003 Package Size: #58003-1 100ul … " - Phospho-acss2

Phospho-acss2

O-GlcNAc transferase regulates glioblastoma acetate metabolism via

WebJul 7, 2024 · ACSS2 has been found to primarily undergo translocation from the cytoplasm to the nucleus . ACSS2 translocation is tightly connected with hormonal and transcription … WebJun 7, 2024 · The authors monitored ACSS2 subcellular localization in human glioblastoma cells and observed that cytosolic ACSS2 translocated into the nucleus when the cells …

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WebJul 21, 2024 · To silence Acly and Acss2, cells were infected with 50 MOI shACLY/shACSS2 adenovectors (Vector BioLabs). To perform co-silencing of Hdac3 and Acly/Acss2, cells at the induction of differentiation ... WebSep 18, 2024 · Acss2 Deletion Protects Against Lipid Deposition and Obesity. To gain insight into the normal physiological function of ACSS2, we compared Acss2 -null mice with …

WebHome > Protein > ACSS2 New Protein Search: Acetyl-coenzyme A synthetase, cytoplasmic Show on y-axis -References (HTP + LTP) References (LTP) References (HTP) log2 … WebMar 21, 2024 · ACSS2 (Acyl-CoA Synthetase Short Chain Family Member 2) is a Protein Coding gene. Diseases associated with ACSS2 include Orofacial Cleft 1 and …

WebNutritional stresses, which restrict acetyl-CoA production from glucose or acetate uptake, result in AMPK-mediated phosphorylation and nuclear translocation of ACSS2. ACSS2 binds to TFEB, translocates to lysosomal and autophagosomal gene promoter regions, and incorporates acetate from histone acetylation turnover to locally produce acetyl-CoA for … WebMar 1, 2024 · VY-3-135 is a potent, stable ACSS2 inhibitor with good bioavailability. (A) Schematic of the forward reaction catalyzed by ACSS2. (B-C) Chemical structures of VY-3-249 and VY-3-135 and IC50 determinations for inhibitors against ACSS1 (blue squares) and ACSS2 (red circles). Data points represent mean (filled shapes) and replicates (empty …

WebJan 21, 2024 · We interrogate whether ACSS2 can facilitate the local transfer of acetyl groups. Our results point to direct transfer of intact acetate that is mediated by ACSS2, underscoring a critical function of acetate transfer in using local and nuclear acetate pools for histone acetylation and rapid transcriptional activation.

WebMay 25, 2024 · In the nucleus, ACSS2 binds to transcription factor EB and translocates to lysosomal and autophagy gene promoter regions, where ACSS2 incorporates acetate generated from histone acetylation turnover to locally produce acetyl-CoA for histone H3 acetylation in these regions and promote lysosomal biogenesis, autophagy, cell survival, … flutter method channel 参数WebMar 8, 2024 · Influenza virus is responsible for respiratory diseases that can be severe or even lethal, especially in young children and the elderly 1.The virus causes annual … green headed sunflowerWebAug 26, 2016 · ACSS2 is highly upregulated in multiple cancer types and may be a useful biomarker for anti-ACSS2 therapies. [ 11 C]acetate has demonstrated excellent potential as an alternative positron emission ... flutter microsoftWebJun 1, 2024 · ACSS2 is phosphorylated at Ser659 by AMPK and then forms a translocation complex with Importin α5 to translocate into the nucleus. This process interacts with TFEB, resulting in upregulated... green headed tree snakeWebSep 18, 2024 · Acetyl-CoA synthetase 2 (ACSS2) is a conserved nucleocytosolic enzyme that converts acetate to acetyl-CoA. Adult mice lacking ACSS2 appear phenotypically normal but exhibit reduced tumor burdens in mouse models of liver cancer. The normal physiological functions of this alternate pathway of acetyl-CoA synthesis remain unclear, … green headed mallard duckWebPhospho (6) Supplier US Biological (50) Biorbyt (48) LSBio (39) Aviva Systems Biology (12) antibodies-online (12) ABclonal (2) Abbexa (9) Abbkine (1) Abcam (5) Abgent (2) ... Anti-ACSS2 antibody produced in rabbit. HPA004141 is a primary antibody from MilliporeSigma. 3 Citations Host: Rabbit Clonality: Polyclonal Validations: None Available greenhead energy operating llcWebACSS2 Antibodies. Santa Cruz Biotechnology, Inc. offers a broad range of ACSS2 antibodies. Select ACSS2 antibodies from monoclonal antibodies listed below. View … flutter method channel ios