Dab2 interacting protein
WebFeb 15, 2024 · Abstract. Disabled-2 (Dab2/DOC-2) is a mitogen-responsive adaptor protein required for multiple cellular functions. It is involved in many signaling pathways and plays an integral role in vesicular uptake and trafficking, modulating immune function, protein … Web智能制造网会员企业上海谷研实业有限公司提供人蛋白激酶Cα相互作用蛋白α1(PICK1)elisa酶联免疫试剂盒介绍,人蛋白激酶Cα相互作用蛋白α1(PICK1)elisa酶联免疫试剂盒介绍 的组成:的安全性:1. 避免直接接触终止液和底物A、B。一旦接触到这些液 …
Dab2 interacting protein
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WebNX_Q5VWQ8 - DAB2IP - Disabled homolog 2-interacting protein - Function. Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, … WebOct 4, 2016 · By interacting with other cellular factors through these motifs, Dab2 elicits its functions in endocytosis, differentiation, and immune response and is involved in the cell signaling pathways of Ras-mitogen activated protein kinase (MAPK), Wnt, TGF-β, c-Src and RhoA-ROCK [24, 27–36].
WebDownload scientific diagram Identi®cation of Dvl-3 as a Dab2-interacting protein. ( A ) Schematic representation of the small-pool cDNA screening strategy using GST±PID. ( B ) Schematic ... WebSep 1, 2024 · DAB2 interacting protein (DAB2IP) was screened as a direct target of miR-1307-3p. The expression of DAB2IP. mRNA was down-regulated and inversely correlated with miR-1307-3p level in HCC tissues ...
WebMay 18, 2010 · The N-terminal half of DAB2IP contains a protein kinase C (see 176960) conserved region-2 (C2) domain and a RasGAP domain. The C-terminal half contains a …
WebNX_P49750 - YLPM1 - YLP motif-containing protein 1 - Interactions. Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation.
WebOct 18, 2024 · Some GAPs can promote apoptosis of tumor cells to protect the organism. p120RasGAP, regulator of G-protein signaling 3 (RGS3), deleted in liver cancer 1 (DLC1), DOC-2/DAB2 interacting protein (DAB2IP), and STARD13 are typical examples because the five GAPs can influence the balance of antiapoptotic proteins and proapoptotic … da pdf a dxf freeDAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcino… birthing bar positionsWebDescription: Homo sapiens DAB2 interacting protein (DAB2IP), transcript variant 1, mRNA. (from RefSeq NM_032552) RefSeq Summary (NM_032552): DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 … da pdf a link onlineWebOct 4, 2012 · Dab2ip (DOC-2/DAB2 interacting protein) is a member of the Ras GTPase-activating protein (GAP) family that has been previously shown to function as a tumor suppressor in several systems. Dab2ip is also highly expressed in the brain where it interacts with Dab1, a key mediator of the Reelin pathway that controls several aspects … birthing bed comfyWebSep 17, 2024 · Meanwhile, the DOC-2/DAB2 interacting protein DAB2IP was previously identified as a member of the Ras-GTPase activating protein family, and functions as a tumor suppressor in cancer progression 7,8. birthing bathtubWebApr 1, 2002 · Human DAB2IP (for DAB2 interaction protein) is a novel member of the RasGTPase-activating protein family. It interacts directly with DAB2, which suppresses growth of many cancer types. We demonstrated that DAB2IP is often downregulated in human prostate cancer cell lines. The predicted DAB2IP protein (967 amino acids) … da pdf a file word gratisWebNov 18, 2016 · The cytoplasmic Ras-GAP protein DAB2IP (Disabled-2 Interacting Protein) is a negative modulator of multiple oncogenic pathways. DAB2IP is rarely mutated, but frequently downregulated or ... birthing beautiful babies