Cspg4-creert
WebArticle Snippet: Cspg4 CreERT2 mice were used to label cardiac pericytes during embryonic development and is a validated model to label Cspg4 expressing cells and were purchased from The Jackson Laboratory (stock number 008538). Techniques: Derivative Assay, Staining, Immunostaining, Expressing. WebFeb 2, 2024 · Chondroitin sulfate proteoglycan 4 (CSPG4) is a multifunctional transmembrane proteoglycan involved in spreading, migration and invasion of melanoma. In addition to the activating BRAF V600E mutation, CSPG4 was shown to promote MAPK signaling by mediating the growth‑factor induced activation of receptor tyrosine kinases. …
Cspg4-creert
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WebDownload scientific diagram Age-related myelin renewal and memory deficits in aging mice a, Schematic diagram displaying the time course of tamoxifen induction and histology in the Cspg4-CreERt ... WebJun 18, 2024 · Chondroitin sulfate proteoglycan 4 (CSPG4) is a potential receptor for C. difficile toxin B (TcdB) during C. difficile infections (CDIs). Here, the cryo-EM structure of a TcdB–CSPG4 complex and ...
WebBy using this site, you agree to our Terms and Conditions Got it! WebFeb 24, 2024 · BackgroundIn triple-negative breast cancer (TNBC), PDL1/PD1-directed immunotherapy is effective in less than 20% of patients. In our preliminary study, we have found CSPG4 to be highly expressed together with PDL1 in TNBCs, particularly those harboring TP53 aberrations. However, the clinical implications of co-expressed CSPG4 …
WebJan 24, 2024 · Mutation details: A cre/ERT2 open reading frame and Frt-flanked neomycin cassette replaced exon 1 of the Cspg4 (NG2) locus following homologous recombination in E14.1 ES cells. The neo cassette was deleted by crossing mice to flp expressing mice. No Cspg4 protein is detected in brain lysates. () WebDownload scientific diagram Segregating mGFP positive pericytes, OPCs and OLs in the Cspg4-CreERt; mT/mG brains a, The blood vessels (red) /pericytes (green) (mT/mG double positive) are ...
WebJul 1, 2024 · CSPG4 plays a central role in the oncogenic pathways required for malignant progression and metastatization. Thanks to these features and to its poor expression in adult healthy tissues, CSPG4 represents an ideal oncoantigen and thus an attractive target for anti-tumor immunotherapy. In this review we explore the potential of CSPG4 immune ...
WebAug 27, 2024 · The NG2-CreERt (The Jackson Laboratory, Catalog # 008538) mouse strain has been described in a previous study (Wang et al., 2024). CreERt expression is under the transcriptional control of the … simply foxedWebDec 14, 2024 · The chondroitin sulfate proteoglycan 4 (CSPG4) gene encodes a transmembrane proteoglycan (PG) constituting the largest and most structurally complex macromolecule of the human surf aceome.Its transcript shows an extensive evolutionary conservation and, due to the elaborated intracellular processing of the translated protein, … ray stevens cannonball runWebCSPG4. Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan ( MCSP) or neuron-glial antigen 2 ( NG2 ), is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene. [5] [6] [7] ray stevens cannonball run lyricsWebCreERT2-P2A expression cassette was knocked into the Cspg4 gene . Research Application ：Cre mouse,Perivascular cell or glial cell. simply fplWebAug 19, 2014 · Chondroitin sulfate proteoglycan 4 (CSPG4) is a promising target antigen that is overexpressed in multiple cancer histologies including melanoma, triple-negative breast cancer, glioblastoma, mesothelioma and sarcoma. Methods: CSPG4 expression in cancer cell lines was assayed using flow cytometry (FACS) and reverse-transcription … simply foyWebSPG4 Hereditary Spastic Paraplegia is caused by a gene mutation. Gene mutations are small errors in our DNA that can cause big problems. Patients with SPG4 have a … simply fox isle of wightWebCreERT系统实现了基因表达的时间控制，在时间要求精准的科学研究中大放异彩。例如，在记忆的研究中，CreERT系统（或TetTag系统），和即刻早期基因一起，经常作为基因 … ray stevens cassettes