Cisplatin hearing loss data

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August undefined, 2024

WebSigns and symptoms seen in children as ototoxicity develops include: High-frequency (≥4 kHz) sensorineural hearing loss that is bilateral (affecting both sides), progressive, and … WebMar 15, 2024 · Cisplatin can cause hearing loss in up to 60% of the treated population, leading to significant impact on QoL. Data from a population-based longitudinal study of age-related hearing impairment (N = 2,688) showed that 28% of adults age 53-97 years …

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WebSep 21, 2016 · Individually, children in this series first showed decreases in hearing after cumulative cisplatin doses ranging between 75 and 600 mg/m 2 and carboplatin doses between 800 and 3,420 mg/m 2. Patients treated for germ cell tumors (Children's Oncology Group 8882) received the highest cumulative doses of cisplatin. WebApr 17, 2024 · Reported rates of cisplatin ototoxicity vary widely, though it is believed that at least half of all patients treated with cisplatin will suffer hearing loss. As cisplatin is … cubic ft size chart for refrigerators

High-dose cisplatin treatment: hearing loss and plasma …

http://mdedge.ma1.medscape.com/fedprac/article/227870/oncology/improving-ototoxicity-monitoring-cisplatin-therapy-va-northeast-ohio WebThirteen percent sustained a significant hearing handicap. An interindividual variation was found, ranging from severe hearing loss after the first course to unaffected hearing after … WebAug 31, 2016 · Ototoxicity poses a major problem to the cancer patient, as the quality of life after receiving cisplatin chemotherapy may be negatively affected due to hearing loss, resulting in social, emotional, and vocational difficulties, as effective communication is … cubic ft to gpm

A Study of Treatment for Medulloblastoma Using Sodium …

WebCisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to … WebOct 11, 2024 · The incidence of hearing loss in humans after aminoglycoside treatment remains unclear due to variable dose stratification regimens and limited pure-tone testing … cubic ft to ft conversionWebFeb 1, 2024 · Tell you doctor right away if you have blood in urine, change in frequency of urination or amount of urine, difficulty in breathing, drowsiness, increased thirst, loss of appetite, nausea or vomiting, swelling of the feet or lower legs, or weakness. cubic ft to psi

"WebMay 19, 2024 · Cisplatin may cause hearing loss as a side effect. In the average-risk medulloblastoma patients, this trial tests whether the addition of sodium thiosulfate (STS) to standard of care chemotherapy and radiation therapy reduces hearing loss. Previous studies with STS have shown that it may help reduce or prevent hearing loss caused by … " - Cisplatin hearing loss data

Cisplatin hearing loss data

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WebTaking a genome-wide association study approach, we identified inherited genetic variations in ACYP2 associated with cisplatin-related ototoxicity (rs1872328: P = 3.9 × 10(-8), hazard ratio = 4.5) in 238 children with newly diagnosed brain tumors, WebFeb 12, 2024 · Overall, the study showed that 44% of pediatric patients treated with cisplatin suffered from moderate to severe hearing loss. But the data showed that not …

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WebFeb 28, 2024 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In … WebApr 6, 2016 · Significance statement: Cisplatin is a widely used chemotherapeutic agent for the treatment of solid tumors. Its use results in significant and permanent hearing loss, for which no US Food and Drug Administration-approved treatment is currently available.

WebJan 4, 2024 · BACKGROUNDCisplatin is widely used to treat adult and pediatric cancers. It is the most ototoxic drug in clinical use, resulting in permanent hearing loss in … Webcisplatin (Rx) Brand and Other Names: Classes: Antineoplastics, Alkylating; Antineoplastics, Platinum Analog Print Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths injectable...

WebAtorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck Cancer Latest version (submitted April 11, 2024) on ClinicalTrials.gov A study version is represented by a row in the table. Select two study versions to compare. One each from columns A and B. WebJan 1, 2024 · The benefits of atorvastatin to the incidence of a CTCAE-defined hearing loss were generally consistent across all subgroups (Figure 3). Overall, 48.8% (156 of 320) of …

Web顺铂治疗导致的永久性听力损失率在 40% 到 80% 之间，并且与相当大的发病率和对生活质量的负面影响有关。目前，没有 FDA 批准的预防顺铂引起的听力损失的疗法。 HMG-CoA 还原酶抑制剂（他汀类药物）由于假定的多效性作用、减少炎症和氧化应激而受到关注。一些临床前和回顾性研究表明，同时服用他汀类药物可以减少顺铂相关的听力损失。目的： …

WebCisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a common side effect of this … eastcote station car parkWebFeb 24, 2024 · Cisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a common side effect of … cubic ft to cubic ydWebFeb 13, 2024 · Overall, the study showed that 44% of pediatric patients treated with cisplatin suffered from moderate to severe hearing loss. But the data showed that not … eastcote taxisWebApr 13, 2024 · Spankovich et al. showed a reduced cisplatin-related hearing loss by cold water irrigation in guinea pigs ( Spankovich et al., 2016 ). In an alternative rodent experiment, the otoprotective effect of hypothermia applied through a custom-made cooling device was evaluated in a cochlea implantation situation. cubic ft to gramsWebModern research on ototoxicity goes back to the 1940s, when streptomycin was introduced into clinical practice. Today, aminoglycoside antibiotics and platinum-based chemotherapy, mainly cisplatin, are the most important drugs that … cubic ft to therm conversionWebApr 7, 2024 · The benefit of Pedmarqsi is preventing cisplatin-induced hearing loss, as evaluated in a phase III, randomised, open-label study in children with standard-risk hepatoblastoma and treated with cisplatin alone or in combination with Pedmarqsi. The most common side effects are vomiting, nausea, hypernatraemia, hypophosphataemia … eastcote taxi cubic ft to metric tons